Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619287 | 0.80 | IDO1 (0.51) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8617541 | 0.79 | HTR5A (0.40) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL3228422 | 0.79 | IDO1 (0.58) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL26731495 | 0.75 | IDO1 (0.53) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2463222 | 0.74 | IDO1 (0.56) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8436958 | 0.74 | IDO1 (0.61) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL26728947 | 0.74 | IDO1 (0.51) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL27626083 | 0.73 | IDO1 (0.54) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL31408101 | 0.73 | IDO1 (0.73) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL16382293 | 0.73 | IDO1 (0.73) | IDO1CYP3A4CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |