Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 15/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 15/20 | 0.38 |
| ▸ | CDK2 | P24941 | 15/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 14/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 14/20 | 0.38 |
| ▸ | MGMT | P16455 | 6/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylguanine SCHEMBL1336757 | 0.84 | CDK1 (0.41) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| Methylguanine SCHEMBL29968306 | 0.84 | CDK1 (0.41) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL8618497 | 0.81 | CDK1 (0.44) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL9682496 | 0.80 | CDK2 (0.59) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL8830293 | 0.78 | CDK1 (0.60) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL12227596 | 0.78 | CDK1 (0.42) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL8537496 | 0.77 | CDK1 (0.44) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL880169 | 0.77 | CDK1 (0.61) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL13160241 | 0.77 | CDK1 (0.43) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL2939763 | 0.77 | MGMT (0.45) | CDK1CCNB1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817799-A | 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-10-06 | — | — | US | claimed |
| EP-0540686-B1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | US COMMERCE (US) | 1995-08-30 | — | — | EP | claimed |
| EP-0540686-A4 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | US COMMERCE (US) | 1993-05-26 | — | — | EP | claimed |
| EP-0540686-A1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES. | US COMMERCE (US) | 1993-05-12 | — | — | EP | claimed |
| WO-1992001700-A1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) | 1992-02-06 | — | — | WO | claimed |
| EP-3489324-A1 | FLUORESCENT PROBE AND PREPARATION METHOD AND USE THEREOF | East China University of Science and Technology (CN) | 2019-05-29 | — | — | EP | disclosed |