Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 7/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619955 | 0.89 | FDFT1 (0.53) | FDFT1 | |
| SCHEMBL8619754 | 0.85 | FDFT1 (0.50) | FDFT1 | |
| SCHEMBL8659011 | 0.85 | FDFT1 (0.56) | FDFT1 | |
| SCHEMBL8622840 | 0.84 | FDFT1 (0.48) | FDFT1 | |
| SCHEMBL8620857 | 0.84 | FDFT1 (0.47) | FDFT1HDAC1 | |
| SCHEMBL8625395 | 0.84 | POLB (0.44) | FDFT1 | |
| SCHEMBL8619968 | 0.84 | POLB (0.47) | FDFT1 | |
| SCHEMBL8624038 | 0.82 | FDFT1 (0.57) | FDFT1 | |
| SCHEMBL8619659 | 0.82 | EPHX2 (0.38) | FDFT1HDAC1EPHX2MMP2MMP3 | |
| SCHEMBL8618653 | 0.82 | FDFT1 (0.44) | FDFT1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |