Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 5/20 | 0.48 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619955 | 0.95 | FDFT1 (0.53) | FDFT1 | |
| SCHEMBL8625395 | 0.88 | POLB (0.44) | FDFT1 | |
| SCHEMBL8619968 | 0.87 | POLB (0.47) | FDFT1 | |
| SCHEMBL8619754 | 0.86 | FDFT1 (0.50) | FDFT1 | |
| SCHEMBL8659011 | 0.86 | FDFT1 (0.56) | FDFT1 | |
| SCHEMBL8618653 | 0.85 | FDFT1 (0.44) | FDFT1 | |
| SCHEMBL8620506 | 0.85 | S1PR1 (0.50) | FDFT1 | |
| SCHEMBL8619655 | 0.84 | FDFT1 (0.44) | FDFT1 | |
| SCHEMBL8624038 | 0.83 | FDFT1 (0.57) | FDFT1 | |
| SCHEMBL8947208 | 0.82 | FDFT1 (0.54) | FDFT1LPAR1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |