Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 9/20 | 0.36 |
| ▸ | TACR2 | P21452 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619741 | 1.00 | TAS1R3 (0.36) | TAS1R3TAS1R1TACR3TACR2ROCK2 | |
| SCHEMBL7353947 | 1.00 | TAS1R3 (0.36) | TAS1R3TAS1R1TACR3TACR2ROCK2 | |
| SCHEMBL7359997 | 0.88 | KCNJ11 (0.40) | TACR3TACR2ROCK2ROCK1TRPV1 | |
| SCHEMBL7359985 | 0.88 | KCNJ11 (0.40) | TACR3TACR2ROCK2ROCK1TRPV1 | |
| SCHEMBL7359989 | 0.88 | KCNJ11 (0.40) | TACR3TACR2ROCK2ROCK1TRPV1 | |
| SCHEMBL13949284 | 0.84 | KMT2A (0.47) | TACR3ROCK2ROCK1TRPV1KDM4E | |
| SCHEMBL8775014 | 0.84 | KMT2A (0.47) | TACR3ROCK2ROCK1TRPV1KDM4E | |
| SCHEMBL4258463 | 0.84 | KMT2A (0.47) | TACR3ROCK2ROCK1TRPV1KDM4E | |
| SCHEMBL7356810 | 0.84 | KMT2A (0.47) | TACR3ROCK2ROCK1TRPV1KDM4E | |
| SCHEMBL7356807 | 0.84 | KMT2A (0.47) | TACR3ROCK2ROCK1TRPV1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | claimed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | claimed |
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |