Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 8/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | MMP14 | P50281 | 2/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623094 | 0.87 | ENPP2 (0.53) | S1PR1S1PR3S1PR2S1PR4ENPP2 | |
| SCHEMBL8618777 | 0.86 | FDFT1 (0.47) | FDFT1MMP2MMP9MMP8MMP13 | |
| SCHEMBL8621425 | 0.85 | FDFT1 (0.50) | S1PR1S1PR3S1PR2S1PR4ENPP2 | |
| SCHEMBL8620466 | 0.85 | FDFT1 (0.46) | S1PR1S1PR3S1PR2S1PR4ENPP2 | |
| SCHEMBL8620713 | 0.83 | FDFT1 (0.54) | S1PR1S1PR3S1PR2S1PR4ENPP2 | |
| SCHEMBL8619882 | 0.81 | S1PR1 (0.49) | S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL8620187 | 0.80 | FDFT1 (0.55) | S1PR1S1PR3S1PR2S1PR4ENPP2 | |
| SCHEMBL8619605 | 0.79 | TAAR1 (0.34) | MMP2MMP9MMP8MMP13MMP14 | |
| SCHEMBL8620898 | 0.79 | ENPP2 (0.60) | S1PR1S1PR3S1PR2S1PR4ENPP2 | |
| SCHEMBL8619964 | 0.78 | FDFT1 (0.61) | S1PR1S1PR3S1PR2S1PR4ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | claimed |
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |