SCHEMBL8620004

SCHEMBL8620004

c1ccc(Nc2ccc(C3(c4ccc(Nc5ccccc5)cc4)CCCCC3)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.52
L3MBTL1 Q9Y468 5/20 0.52
HSD17B10 Q99714 4/20 0.52
ALOX12 P18054 4/20 0.52
TDP1 Q9NUW8 4/20 0.52
ALOX15 P16050 3/20 0.52
TSHR P16473 3/20 0.52
MAPK1 P28482 3/20 0.52
HTR2B P41595 2/20 0.52
PTGS1 P23219 1/20 0.52
SLC6A2 P23975 1/20 0.52
PTGS2 P35354 1/20 0.52
ESR1 P03372 2/20 0.50
ESR2 Q92731 2/20 0.50
MAPT P10636 5/20 0.49
LMNA P02545 4/20 0.49
HTT P42858 3/20 0.49
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
THRB P10828 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17666366 0.94 ALDH1A1 (0.46) ALDH1A1L3MBTL1HSD17B10ALOX12TDP1
SCHEMBL1021921 0.85 HPGD (0.57) ALDH1A1ALOX12HTR2BMAPTLMNA
SCHEMBL8647058 0.84 ALDH1A1 (0.39) ALDH1A1L3MBTL1HSD17B10ALOX12TDP1
SCHEMBL2046010 0.82 MAPT (0.51) ALDH1A1L3MBTL1ALOX12HTR2BESR1
SCHEMBL24157288 0.80 ESR1 (0.58) ALDH1A1L3MBTL1SLC6A2ESR1ESR2
SCHEMBL28378542 0.80 ESR1 (0.58) ALDH1A1L3MBTL1SLC6A2ESR1ESR2
SCHEMBL30877914 0.80 ESR1 (0.58) ALDH1A1L3MBTL1SLC6A2ESR1ESR2
SCHEMBL30877902 0.80 ESR1 (0.58) ALDH1A1L3MBTL1SLC6A2ESR1ESR2
SCHEMBL30078304 0.80 ESR1 (0.58) ALDH1A1L3MBTL1SLC6A2ESR1ESR2
SCHEMBL54982 0.80 ESR1 (0.58) ALDH1A1L3MBTL1SLC6A2ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100028047-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR AND IMAGE FORMING APPARATUS SHARP KABUSHIKI KAISHA (JP) 2010-02-04 US disclosed
US-20100028047-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR AND IMAGE FORMING APPARATUS SHARP KABUSHIKI KAISHA (JP) 2010-02-04 US disclosed
EP-0650955-B1 Amine compound and electro-luminescence device comprising same HODOGAYA CHEMICAL CO LTD (JP) 1998-08-19 EP disclosed
EP-0452681-B1 Electrostatographic imaging member containing polyarylamine polymers XEROX CORP (US) 1998-06-03 EP disclosed
US-5707747-A CHARGE TRANSPORT COMPOUNDS HODOGAYA CHEMICAL CO., LTD. (JP) 1998-01-13 US disclosed
EP-0452682-B1 Polyarylamine polymers XEROX CORP (US) 1997-09-17 EP disclosed
US-5639914-A DURABLE, STABLE, LOW VOLTAGE ELECTROLUMINESCENT EMITTERS HODOGAYA CHEMICAL CO., LTD. (JP) 1997-06-17 US disclosed
EP-0650955-A1 Amine compound and electro-luminescence device comprising same HODOGAYA CHEMICAL CO., LTD. (JP) 1995-05-03 EP disclosed
US-5356743-A Electrophotographic imaging members containing polyarylamine polyesters XEROX CORPORATION (US) 1994-10-18 US disclosed
EP-0295113-B1 Polyarylamine compounds XEROX CORP (US) 1994-02-02 EP disclosed
US-5283143-A Electrophotographic imaging member containing arylamine terpolymers with CF3 substituted moieties XEROX CORPORATION (US) 1994-02-01 US disclosed
US-5262512-A Polyarylamine polyesters XEROX CORPORATION (US) 1993-11-16 US disclosed
US-5202408-A Arylamine containing terpolymers with CF3 substituted moieties XEROX CORPORATION (US) 1993-04-13 US disclosed
US-5155200-A Polyurethanes from dihydroxyarylamine compounds XEROX CORPORATION (US) 1992-10-13 US disclosed
EP-0452682-A2 Polyarylamine polymers XEROX CORPORATION (US) 1991-10-23 EP disclosed
EP-0452681-A2 Systems utilizing polyarylamine polymers XEROX CORPORATION (US) 1991-10-23 EP disclosed
US-5030532-A Electrophotographic imaging member utilizing polyarylamine polymers XEROX CORPORATION (US) 1991-07-09 US disclosed
US-4801517-A Polyarylamine compounds and systems utilizing polyarylamine compounds XEROX CORPORATION (US) 1989-01-31 US disclosed
EP-0295113-A2 Polyarylamine compounds XEROX CORPORATION (US) 1988-12-14 EP disclosed