SCHEMBL8620145

SCHEMBL8620145

OCCCCCCc1ccccc1-c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.50
KMT2A Q03164 1/20 0.47
PTGER1 P34995 3/20 0.45
PTGER4 P35408 3/20 0.45
PTGER3 P43115 3/20 0.45
PTGER2 P43116 3/20 0.45
FOLH1 Q04609 1/20 0.45
PDCD1 Q15116 1/20 0.44
CD274 Q9NZQ7 1/20 0.44
PPARA Q07869 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
BCL2L1 Q07817 2/20 0.40
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL17044572 0.98 DPP4 (0.48) DPP4KMT2APTGER1PTGER4PTGER3
SCHEMBL11334269 0.98 DPP4 (0.52) DPP4KMT2APTGER1PTGER4PTGER3
SCHEMBL1535892 0.92 DPP4 (0.54) DPP4KMT2APTGER1PTGER4PTGER3
SCHEMBL12506252 0.85 DPP4 (0.60) DPP4KMT2APTGER1PTGER4PTGER3
SCHEMBL27840283 0.83 DPP4 (0.58) DPP4KMT2APTGER1PTGER4PTGER3
SCHEMBL429540 0.83 DPP4 (0.58) DPP4KMT2APTGER1PTGER4PTGER3
SCHEMBL2178352 0.83 LIPG (0.47) CA2BCL2L1BIDMCL1BAK1
SCHEMBL3726514 0.82 LIPG (0.55) DPP4PPARABCL2L1BIDMCL1
SCHEMBL2303757 0.82 LIPG (0.55) DPP4PPARABCL2L1BIDMCL1
SCHEMBL251097 0.82 LIPG (0.55) DPP4PPARABCL2L1BIDMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5712396-A PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS MAGNIN DAVID R (US) 1998-01-27 US disclosed
US-5567841-A ANTICHOLESTEROL AGENT BRISTOL-MYERS SQUIBB COMPANY (US) 1996-10-22 US disclosed
US-5470845-A Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia BRISTOL-MYERS SQUIBB COMPANY (US) 1995-11-28 US disclosed
EP-0595635-A1 Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors E.R. Squibb & Sons, Inc. (US) 1994-05-04 EP disclosed