Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 5/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555183 | 0.99 | CYP2D6 (0.49) | CYP2D6MEN1KMT2ATACR1CFTR | |
| SCHEMBL6555294 | 0.87 | MEN1 (0.61) | MEN1KMT2ATACR1L3MBTL1LMNA | |
| SCHEMBL6556099 | 0.85 | MEN1 (0.60) | MEN1KMT2ATACR1L3MBTL1LMNA | |
| SCHEMBL6556931 | 0.85 | MEN1 (0.60) | MEN1KMT2ATACR1L3MBTL1LMNA | |
| SCHEMBL8621981 | 0.85 | TACR1 (0.48) | CYP2D6MEN1KMT2ATACR1CFTR | |
| SCHEMBL8620048 | 0.85 | SGPL1 (0.49) | MEN1KMT2AGAAL3MBTL1SGPL1 | |
| SCHEMBL7713389 | 0.85 | TACR1 (0.48) | CYP2D6MEN1KMT2ATACR1CFTR | |
| Hydrochloric Acid SCHEMBL8620287 | 0.84 | MEN1 (0.59) | MEN1KMT2ATACR1L3MBTL1LMNA | |
| SCHEMBL6555248 | 0.84 | MEN1 (0.61) | MEN1KMT2ATACR1L3MBTL1LMNA | |
| SCHEMBL6556838 | 0.84 | SGPL1 (0.48) | MEN1KMT2AGAAL3MBTL1SGPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613458-B1 | ACYCLIC ETHYLENEDIAMINE DERIVATIVES AS SUBSTANCE P RECEPTOR ANTAGONISTS | PFIZER (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5521220-A | Acyclic ethylenediamine derivatives | PFIZER INC. (US) | 1996-05-28 | — | — | US | disclosed |
| WO-1993010073-A1 | ACYCLIC ETHYLENEDIAMINE DERIVATIVES AS SUBSTANCE P RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1993-05-27 | — | — | WO | disclosed |