Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 3/20 | 0.37 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625401 | 0.87 | POLB (0.45) | POLBALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL8620902 | 0.85 | NR1I2 (0.42) | NR1I2CETPNAAA | |
| SCHEMBL8618661 | 0.83 | POLB (0.48) | POLBALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL8624267 | 0.82 | TP53 (0.46) | — | |
| SCHEMBL8620506 | 0.77 | S1PR1 (0.50) | ALDH1A1LMNAKDM4E | |
| Phosphoric Acid SCHEMBL15475811 | 0.77 | CETP (0.47) | NR1I2CETPNAAACYSLTR2CYSLTR1 | |
| SCHEMBL8619968 | 0.76 | POLB (0.47) | POLBALDH1A1LMNAKDM4E | |
| SCHEMBL8624044 | 0.76 | POLB (0.48) | POLBALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL8622840 | 0.75 | FDFT1 (0.48) | — | |
| SCHEMBL9641527 | 0.74 | S1PR2 (0.48) | NR1I2ALDH1A1NAAACYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |