Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTSR1 | P30989 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.33 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856582 | 0.92 | NCF1 (0.42) | CREBBPPOLBEHMT2EHMT1NCF1 | |
| SCHEMBL857227 | 0.84 | PDGFRB (0.41) | CREBBPPOLBEHMT2EHMT1NCF1 | |
| SCHEMBL857240 | 0.81 | NCF1 (0.48) | CREBBPEHMT2EHMT1NCF1KDR | |
| SCHEMBL857428 | 0.76 | NCF1 (0.45) | EHMT2EHMT1NCF1KDR | |
| SCHEMBL856776 | 0.73 | CREBBP (0.48) | CREBBPNCF1PIK3CA | |
| SCHEMBL857346 | 0.72 | NCF1 (0.45) | EHMT2EHMT1NCF1KDRPIK3CA | |
| SCHEMBL857885 | 0.72 | GBA1 (0.43) | MEN1KMT2ACREBBPMAPTPOLB | |
| SCHEMBL3763643 | 0.71 | NCF1 (0.47) | CREBBPEHMT2EHMT1NCF1KDR | |
| SCHEMBL859609 | 0.70 | NCF1 (0.42) | EHMT2EHMT1NCF1KDRPIK3CA | |
| SCHEMBL858428 | 0.70 | NCF1 (0.42) | EHMT2EHMT1NCF1KDRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |