Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 5/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | LITAF | Q99732 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | WEE1 | P30291 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL862326 | 0.94 | CYP2C8 (0.38) | CYP2C8SCN7ASCN5AALDH1A1KDM4E | |
| SCHEMBL10256117 | 0.91 | SCN9A (0.39) | CYP2C8SCN5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL862363 | 0.91 | KMT2A (0.34) | CYP2C8SCN7ASCN5AALDH1A1KDM4E | |
| SCHEMBL10256960 | 0.91 | CHRM1 (0.37) | CYP2C8ALDH1A1KDM4ECYP1A2HPGD | |
| SCHEMBL10255118 | 0.86 | SCN9A (0.40) | CYP2C8ALDH1A1KDM4ECYP1A2HPGD | |
| SCHEMBL12890345 | 0.85 | SCN9A (0.33) | CYP2C8SCN7ASCN5AALDH1A1KDM4E | |
| SCHEMBL831565 | 0.84 | ALDH1A1 (0.40) | CYP2C8SCN5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL862037 | 0.83 | KMT2A (0.44) | MAPK8CYP2C8ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL831574 | 0.83 | KDM4E (0.41) | CYP2C8SCN5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL862067 | 0.82 | KMT2A (0.50) | MAPK8CYP2C8ALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | IDO2, IDO1, IRF3 | MAPK8 4136/4885CYP2C8 847/4885SCN7A 3535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.