Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620809 | 0.82 | SLC6A2 (0.47) | CYP2C19SLC6A2SLC6A3SLC6A4ADRB2 | |
| SCHEMBL8623862 | 0.79 | GAA (0.40) | SLC6A2SLC6A3KDR | |
| SCHEMBL8619656 | 0.79 | SLC6A2 (0.36) | CYP2C19SLC6A2SLC6A3ADRB2CYP2D6 | |
| SCHEMBL8627137 | 0.75 | SLC6A2 (0.52) | SLC6A2SLC6A3SLC6A4ADRB2SIGMAR1 | |
| SCHEMBL20495645 | 0.75 | CYP1A2 (0.47) | CYP1A2CYP2C19CTNNB1TACR1ADRB2 | |
| SCHEMBL30119544 | 0.75 | CYP1A2 (0.47) | CYP1A2CYP2C19CTNNB1TACR1ADRB2 | |
| SCHEMBL31054201 | 0.74 | HTR2A (0.55) | CYP1A2CYP2C19CTNNB1SLC6A2SLC6A3 | |
| SCHEMBL31054151 | 0.74 | HTR2A (0.55) | CYP1A2CYP2C19CTNNB1SLC6A2SLC6A3 | |
| SCHEMBL266931 | 0.74 | HTR2A (0.55) | CYP1A2CYP2C19CTNNB1SLC6A2SLC6A3 | |
| SCHEMBL8618784 | 0.74 | HTR2A (0.58) | CYP1A2SLC6A2SLC6A3TACR1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5777150-A | Substituted amic acid derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-07-07 | — | — | US | disclosed |
| EP-0611749-B1 | Substituted amic acid derivatives useful for treatment of arteriosclerosis | BANYU PHARMA CO LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| US-5616803-A | EXHIBIT SQUALENE SYNTHASE-INHIBITORY ACTIVITIES; USEFUL IN TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA, HYPERLIPEMIA AND ARTERIOSCLEROSIS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-04-01 | — | — | US | disclosed |
| US-5606101-A | INTERMEDIATES FOR SQUALENE SYNTHASE INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5488149-A | SQUALENE SYNTHASE INHIBITORS AS ANTICHOLESTEROL OR ANTILIPEMIC AGENTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1996-01-30 | — | — | US | disclosed |
| EP-0611749-A1 | Substituted amic acid derivatives useful for treatment of arteriosclerosis | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-08-24 | — | — | EP | disclosed |