Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621733 | 0.79 | CYP1A2 (0.44) | KDRSLC6A2SLC6A3 | |
| SCHEMBL8620809 | 0.75 | SLC6A2 (0.47) | L3MBTL1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL8619656 | 0.74 | SLC6A2 (0.36) | LMNAKMT2AMEN1HTR2AHTR2C | |
| SCHEMBL585843 | 0.74 | PSMD14 (0.50) | GAAL3MBTL1TP53MAPTLMNA | |
| SCHEMBL4111893 | 0.69 | KMT2A (0.36) | GAAL3MBTL1PDE4APDE4BPDE4C | |
| SCHEMBL4691720 | 0.69 | SLC6A3 (0.62) | SMN1; SMN2KMT2ARAB9AMEN1SLC6A2 | |
| SCHEMBL8622261 | 0.69 | SLC6A2 (0.49) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| SCHEMBL13068399 | 0.69 | HTT (0.47) | TP53LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1285335 | 0.69 | PARP1 (0.50) | GAAL3MBTL1TP53MAPTLMNA | |
| SCHEMBL4990218 | 0.69 | KDM4E (0.54) | L3MBTL1TP53MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5777150-A | Substituted amic acid derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-07-07 | — | — | US | disclosed |
| EP-0611749-B1 | Substituted amic acid derivatives useful for treatment of arteriosclerosis | BANYU PHARMA CO LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| US-5616803-A | EXHIBIT SQUALENE SYNTHASE-INHIBITORY ACTIVITIES; USEFUL IN TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA, HYPERLIPEMIA AND ARTERIOSCLEROSIS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-04-01 | — | — | US | disclosed |
| US-5606101-A | INTERMEDIATES FOR SQUALENE SYNTHASE INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5488149-A | SQUALENE SYNTHASE INHIBITORS AS ANTICHOLESTEROL OR ANTILIPEMIC AGENTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1996-01-30 | — | — | US | disclosed |
| EP-0611749-A1 | Substituted amic acid derivatives useful for treatment of arteriosclerosis | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-08-24 | — | — | EP | disclosed |