Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.73 |
| ▸ | BACE1 | P56817 | 6/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.73 |
| ▸ | GAA | P10253 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | APEX1 | P27695 | 3/20 | 0.73 |
| ▸ | RECQL | P46063 | 3/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.73 |
| ▸ | PKM | P14618 | 2/20 | 0.73 |
| ▸ | ALPL | P05186 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.73 |
| ▸ | SNCA | P37840 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13099978 | 1.00 | KDM4E (0.73) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL862117 | 0.94 | BACE1 (0.63) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL1974812 | 0.93 | BACE1 (0.62) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL862110 | 0.93 | BACE1 (0.62) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL25246785 | 0.89 | CYP3A4 (0.78) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL862416 | 0.89 | CYP3A4 (0.78) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL15220850 | 0.88 | KDM4E (0.73) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL21585683 | 0.88 | BACE1 (0.71) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL13099977 | 0.88 | BACE1 (0.71) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL21621483 | 0.87 | KDM4E (0.68) | KDM4EBACE1PTGS1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143308-B2 | Synthesis of oligo/poly(catechins) and methods of use | UNIVERSITY OF MASSACHUSETTS LOWELL (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100266523-A1 | COMPOSITIONS CONTAINING FLAVANOID POLYPHENOL DERIVATIVES, AND APPLICATIONS THEREOF IN CONTROLLING DISEASES AND AGEING OF LIVING ORGANISMS | CAUDALIE (FR) | 2010-10-21 | — | — | US | disclosed |
| US-20100266523-A1 | COMPOSITIONS CONTAINING FLAVANOID POLYPHENOL DERIVATIVES, AND APPLICATIONS THEREOF IN CONTROLLING DISEASES AND AGEING OF LIVING ORGANISMS | CAUDALIE (FR) | 2010-10-21 | — | — | US | disclosed |
| US-20090170928-A1 | Synthesis of oligo/poly(catechins) and methods of use | GOVERNMENT OF THE UNITED STATES | 2009-07-02 | — | — | US | disclosed |
| WO-2009063439-A1 | COMPOSITIONS CONTAINING FLAVANOID POLYPHENOL DERIVATIVES, AND APPLICATIONS THEREOF IN CONTROLLING DISEASES AND AGEING OF LIVING ORGANISMS | CAUDALIE (FR) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170928-A1 | Synthesis of oligo/poly(catechins) and methods of use | POLI, PUF60, FABP3 | KDM4E 3150/4885BACE1 4807/4885PTGS1 1613/4885 |
| US-20100266523-A1 | COMPOSITIONS CONTAINING FLAVANOID POLYPHENOL DERIVATIVES, AND APPLICATIONS THEREOF IN CONTROLLING DISEASES AND AGEING OF LIVING ORGANISMS | FABP4, PPARG, FANCI | KDM4E 1736/4885BACE1 909/4885PTGS1 543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.