Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8624041 | 0.88 | FDFT1 (0.45) | FFAR1LTA4HFDFT1POLB | |
| SCHEMBL8622237 | 0.82 | FDFT1 (0.44) | LPAR1LPAR5FFAR1MAPK14PTGS2 | |
| SCHEMBL8625399 | 0.81 | POLB (0.42) | FDFT1POLB | |
| SCHEMBL8618660 | 0.81 | POLB (0.42) | LTA4HPOLB | |
| SCHEMBL8623400 | 0.81 | FFAR1 (0.44) | FFAR1LTA4H | |
| SCHEMBL8619659 | 0.78 | EPHX2 (0.38) | FDFT1POLB | |
| SCHEMBL8947010 | 0.74 | S1PR1 (0.36) | L3MBTL1 | |
| SCHEMBL8622277 | 0.73 | FDFT1 (0.47) | LPAR1LPAR5FFAR1MAPK14FDFT1 | |
| SCHEMBL8620192 | 0.72 | FDFT1 (0.43) | MMP14FDFT1THRB | |
| SCHEMBL8624038 | 0.69 | FDFT1 (0.57) | FFAR1FDFT1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |