Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 2/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618660 | 0.93 | POLB (0.42) | POLBMEN1KMT2AGAAKDM4E | |
| SCHEMBL8624041 | 0.88 | FDFT1 (0.45) | POLBS1PR1GAAFDFT1 | |
| SCHEMBL8620511 | 0.88 | S1PR1 (0.52) | S1PR2S1PR1S1PR3S1PR4KDM4E | |
| SCHEMBL8623400 | 0.88 | FFAR1 (0.44) | MEN1KMT2A | |
| SCHEMBL8619659 | 0.82 | EPHX2 (0.38) | POLBGAAFDFT1 | |
| SCHEMBL8622242 | 0.81 | LPAR1 (0.39) | POLBFDFT1 | |
| SCHEMBL8625395 | 0.81 | POLB (0.44) | POLBMEN1KMT2AGAAFDFT1 | |
| SCHEMBL8619968 | 0.78 | POLB (0.47) | POLBMEN1KMT2AGAAKDM4E | |
| SCHEMBL8947010 | 0.78 | S1PR1 (0.36) | S1PR2S1PR1S1PR3S1PR4ALDH1A1 | |
| SCHEMBL8618653 | 0.77 | FDFT1 (0.44) | POLBMEN1KMT2AGAAFDFT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |