⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878850 | 0.90 | GCGR (0.39) | — | |
| SCHEMBL8876530 | 0.88 | HMGCR (0.34) | — | |
| SCHEMBL8877571 | 0.87 | PRKAA2 (0.35) | — | |
| SCHEMBL8877574 | 0.86 | HMGCR (0.39) | — | |
| SCHEMBL8878296 | 0.84 | DHODH (0.37) | — | |
| SCHEMBL8877422 | 0.83 | — | — | |
| SCHEMBL8877505 | 0.83 | HMGCR (0.40) | — | |
| SCHEMBL8875676 | 0.82 | GCGR (0.38) | — | |
| SCHEMBL8877566 | 0.81 | HMGCR (0.40) | — | |
| SCHEMBL8900189 | 0.81 | GCGR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |