Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876255 | 0.92 | PRKAA2 (0.34) | PRKAA2RXRAHMGCRNR1I2NR4A2 | |
| SCHEMBL8622348 | 0.87 | — | — | |
| SCHEMBL8876530 | 0.85 | HMGCR (0.34) | HMGCR | |
| SCHEMBL8877311 | 0.85 | PRKAA2 (0.37) | PRKAA2RXRAHMGCRNR1I2NR4A2 | |
| SCHEMBL8877719 | 0.84 | PRKAA2 (0.35) | PRKAA2RXRAHMGCRNR1I2NR4A2 | |
| SCHEMBL8877322 | 0.80 | PRKAA2 (0.34) | PRKAA2RXRAHMGCR | |
| SCHEMBL8900806 | 0.78 | ADORA3 (0.33) | — | |
| SCHEMBL8878850 | 0.77 | GCGR (0.39) | HMGCR | |
| SCHEMBL8877566 | 0.77 | HMGCR (0.40) | HMGCR | |
| SCHEMBL8876250 | 0.76 | NR1I2 (0.39) | PRKAA2RXRAHMGCRNR1I2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |