Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL640338 | 0.87 | CYP2C9 (0.59) | CYP2C19CYP2C9MAPTHTTSMN1; SMN2 | |
| SCHEMBL4908272 | 0.86 | LMNA (0.59) | CYP2C19CYP2C9KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5372083 | 0.85 | CYP2C9 (0.65) | CYP2C19CYP2C9KMT2AMAPTHTT | |
| SCHEMBL640295 | 0.84 | CYP11B1 (0.60) | CYP2C19CYP2C9KMT2AMAPTL3MBTL1 | |
| SCHEMBL640459 | 0.83 | CYP2C9 (0.55) | CYP2C19CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL29597594 | 0.83 | CYP2C19 (0.70) | CYP2C19CYP2C9MAPTHTTSMN1; SMN2 | |
| SCHEMBL158686 | 0.83 | CYP2C19 (0.70) | CYP2C19CYP2C9MAPTHTTSMN1; SMN2 | |
| SCHEMBL14017822 | 0.83 | CYP2C19 (0.57) | CYP2C19CYP2C9KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL640303 | 0.82 | MAOB (0.54) | CYP2C19CYP2C9KMT2AMAPTMEN1 | |
| SCHEMBL6705884 | 0.81 | CA12 (0.61) | CYP2C19CYP2C9KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714496-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHERSCLEROSIS | ZENECA LIMITED (GB) | 1998-02-03 | — | — | US | disclosed |
| EP-0656897-B1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LTD (GB) | 1998-01-07 | — | — | EP | disclosed |
| EP-0656897-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-14 | — | — | EP | disclosed |
| WO-1994005660-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-03-17 | — | — | WO | disclosed |