Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 13/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.60 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.58 |
| ▸ | PGR | P06401 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | GC | P02774 | 1/20 | 0.58 |
| ▸ | RXRA | P19793 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8401495 | 0.94 | VDR (0.65) | VDRADORA3SLC6A2AGTR1MAPT | |
| SCHEMBL8401466 | 0.91 | VDR (0.65) | VDRADORA3SLC6A2AGTR1MAPT | |
| SCHEMBL8400107 | 0.88 | HDAC6 (0.56) | VDRCYP24A1 | |
| SCHEMBL8400480 | 0.87 | VDR (0.69) | VDRADORA3SLC6A2AGTR1NR1I2 | |
| SCHEMBL8398624 | 0.86 | VDR (0.47) | VDRCYP24A1 | |
| SCHEMBL7132166 | 0.84 | VDR (0.75) | VDRADORA3SLC6A2AGTR1MAPT | |
| SCHEMBL8400127 | 0.84 | VDR (0.47) | VDRADORA3SLC6A2AGTR1MAPT | |
| SCHEMBL8398550 | 0.84 | VDR (0.47) | VDRADORA3SLC6A2AGTR1MAPT | |
| Ecalcidene SCHEMBL29387604 | 0.83 | VDR (0.71) | VDRADORA3SLC6A2AGTR1MAPT | |
| SCHEMBL8063329 | 0.83 | VDR (0.73) | VDRADORA3SLC6A2AGTR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811562-A | Vitamin-D amide derivatives | RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY INC. (US) | 1998-09-22 | — | — | US | disclosed |