⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16103827 | 0.59 | — | — | |
| SCHEMBL10337568 | 0.59 | — | — | |
| SCHEMBL15561404 | 0.57 | S100A4 (0.30) | — | |
| SCHEMBL1894595 | 0.55 | — | — | |
| SCHEMBL10499286 | 0.53 | — | — | |
| SCHEMBL2455006 | 0.52 | KDM4E (0.33) | — | |
| SCHEMBL10790955 | 0.52 | — | — | |
| SCHEMBL5115934 | 0.52 | — | — | |
| SCHEMBL5842299 | 0.50 | — | — | |
| SCHEMBL10884014 | 0.50 | TLR4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843939-A | Derivatives of 3-bromo- and 3,3-dibromo-4-oxo-1-azetidines, processes for the preparation thereof and their use | PLIVA, FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA, DIONICKO DRUSTVO (HR) | 1998-12-01 | — | — | US | disclosed |
| EP-0791580-A2 | Novel derivatives of 3-bromo and 3,3-dibromo-4-oxo-1-azetidines, processes for the preparation thereof and their use | PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo (HR) | 1997-08-27 | — | — | EP | disclosed |
| EP-0022628-B1 | PROCESS FOR THE PREPARATION OF OXAZOLINOAZETIDINONES | ELI LILLY AND COMPANY (US) | 1983-06-22 | — | — | EP | disclosed |
| US-4357275-A | Novel oxazolinoazetidinones and process therefor | ELI LILLY AND COMPANY (US) | 1982-11-02 | — | — | US | disclosed |
| EP-0011369-B1 | PROCESS FOR PREPARING 3-EXOMETHYLENECEPHAM SULFOXIDES | ELI LILLY AND COMPANY (US) | 1982-03-24 | — | — | EP | disclosed |
| EP-0022628-A1 | Process for the preparation of oxazolinoazetidinones | ELI LILLY AND COMPANY (US) | 1981-01-21 | — | — | EP | disclosed |
| US-4243588-A | CYCLIZING A 2-CHLOROAZETIDINONE WITH LEAD FLUORIDE IN DIMETHYL SULFOXIDE TO OBTAIN THE 4-OXA-2,6-DIAZABICYCLO(3.2.0)HEPTANE | ELI LILLY AND COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| US-4243588-A | CYCLIZING A 2-CHLOROAZETIDINONE WITH LEAD FLUORIDE IN DIMETHYL SULFOXIDE TO OBTAIN THE 4-OXA-2,6-DIAZABICYCLO(3.2.0)HEPTANE | ELI LILLY AND COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| EP-0011369-A1 | Process for preparing 3-exomethylenecepham sulfoxides | ELI LILLY AND COMPANY (US) | 1980-05-28 | — | — | EP | disclosed |
| US-4195021-A | 1,3-Disubstituted 2-azetidinone antibitotics | ELI LILLY AND COMPANY (US) | 1980-03-25 | — | — | US | disclosed |
| US-4190724-A | Process for 3-exomethylenecepham sulfoxides | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| EP-0001715-A2 | Azetidinone antibiotics and their pharmaceutical formulations and use | ELI LILLY AND COMPANY (US) | 1979-05-02 | — | — | EP | disclosed |