Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11176934 | 0.95 | PTGS2 (0.68) | PTGS2PTGS1ADORA3KDM4EMEN1 | |
| SCHEMBL11182826 | 0.88 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL11186397 | 0.88 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL11181115 | 0.87 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL11189224 | 0.86 | PTGS2 (0.58) | PTGS2PTGS1ADORA3KDM4EMEN1 | |
| SCHEMBL11177588 | 0.84 | PTGS2 (0.81) | PTGS2PTGS1 | |
| SCHEMBL11176910 | 0.83 | PTGS2 (0.54) | PTGS2PTGS1ADORA3KDM4EMEN1 | |
| SCHEMBL11176908 | 0.83 | PTGS2 (0.54) | PTGS2PTGS1ADORA3KDM4EMEN1 | |
| SCHEMBL11180756 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1ADORA3KDM4EMEN1 | |
| SCHEMBL11180753 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1ADORA3KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009554-B1 | INDANYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-04-27 | — | — | EP | claimed |
| US-4244960-A | HERBICIDES OR ANTIINFLAMMATORY AGENTS | SCHERING, AKTIENGESELLSCHAFT (DE) | 1981-01-13 | — | — | US | claimed |
| EP-0009554-A1 | Indanyl derivatives, process for their preparation and pharmaceutical compositions containing these compounds | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-04-16 | — | — | EP | claimed |
| US-5811416-A | ADMINISTERING TO TREAT DISORDERS SUCH AS DYSMENORRHEA, PRETERM LABOR, PREECLAMPSIA, OR FETAL GROWTH RETARDATION; ALSO HORMONE REPLACEMENT THERAPY, HYPERTENSION | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0844884-A2 | ENDOTHELIN ANTAGONISTS AND ENDOTHELIN SYNTHASE INHIBITORS FOR THE PREVENTION AND TREATMENT OF UTERINE CONTRACTILITY DISORDERS, PREECLAMPSIA, ATHEROSCLEROTIC VASCULAR DISEASE, HYPERTENSION AND FOR HORMONE REPLACEMENT THERAPY | CHWALISZ, Krzysztof (DE) | 1998-06-03 | — | — | EP | disclosed |
| WO-1996035453-A2 | ENDOTHELIN ANTAGONISTS AND ENDOTHELIN SYNTHASE INHIBITORS FOR THE PREVENTION AND TREATMENT OF INTERINE CONTRACTILITY DISORDERS, PREECLAMPSIA, ATHEROSCLEROTIC VASCULAR DISEASE, HYPERTENSION AND OR HORMONE REPLACEMENT THERAPY | CHWALISZ KRISTOF (DE) | 1996-11-14 | — | — | WO | disclosed |
| EP-0143403-B1 | PROCESS FOR THE PREPARATION OF INDANE DERIVATIVES, AND THEIR USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4696948-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-09-29 | — | — | US | disclosed |
| EP-0143403-A2 | Process for the preparation of indane derivatives, and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-06-05 | — | — | EP | disclosed |
| EP-0009554-B1 | INDANYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-04-27 | — | — | EP | disclosed |
| US-4244960-A | HERBICIDES OR ANTIINFLAMMATORY AGENTS | SCHERING, AKTIENGESELLSCHAFT (DE) | 1981-01-13 | — | — | US | disclosed |
| EP-0009554-A1 | Indanyl derivatives, process for their preparation and pharmaceutical compositions containing these compounds | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-04-16 | — | — | EP | disclosed |