Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.75 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.75 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.75 |
| ▸ | SHBG | P04278 | 2/20 | 0.75 |
| ▸ | PGR | P06401 | 2/20 | 0.75 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.75 |
| ▸ | AR | P10275 | 2/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.75 |
| ▸ | SNCA | P37840 | 2/20 | 0.75 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.75 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.75 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | STS | P08842 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623738 | 1.00 | ESR1 (0.75) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL17814221 | 1.00 | ESR1 (0.75) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL17808700 | 0.88 | ESR1 (0.71) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| Estriol SCHEMBL4287011 | 0.87 | ESR1 (0.93) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL7526040 | 0.87 | ESR1 (0.69) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL7518726 | 0.87 | LMNA (0.71) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL1999916 | 0.87 | LMNA (0.71) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL1999913 | 0.87 | LMNA (0.71) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL7526045 | 0.87 | ESR1 (0.69) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| Estriol SCHEMBL23743979 | 0.86 | ESR1 (1.00) | ESR1ESR2LMNACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5709844-A | HUMAN PAPILLOMAVIRUS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-01-20 | — | — | US | disclosed |
| US-5698764-A | Transgenic mice expressing HPV early region oncogene develop progressive epithelial neoplasia | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-12-16 | — | — | US | disclosed |
| WO-1995033826-A1 | TRANSGENIC MICE EXPRESSING PROGRESSIVE CERVICO-VAGINAL NEOPLASIA | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995033820-A1 | TRANSGENIC MICE EXPRESSING PROGRESSIVE EPITHELIAL NEOPLASIA | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-14 | — | — | WO | disclosed |