Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 16/20 | 0.43 |
| ▸ | EDNRB | P24530 | 11/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945233 | 0.92 | EDNRA (0.46) | EDNRAEDNRBSCN9A | |
| SCHEMBL8626017 | 0.89 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL8622698 | 0.86 | SCN9A (0.46) | EDNRAEDNRBSCN9A | |
| SCHEMBL8622873 | 0.84 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL8620434 | 0.84 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL7538297 | 0.83 | SCN9A (0.46) | EDNRAEDNRBSCN9A | |
| SCHEMBL8623907 | 0.76 | PRKCI (0.46) | EDNRAEDNRBSCN9A | |
| SCHEMBL7534451 | 0.74 | EDNRA (0.48) | EDNRAEDNRBSCN9A | |
| SCHEMBL8625510 | 0.73 | EDNRB (0.43) | EDNRAEDNRBHSP90AA1HSP90AB1 | |
| SCHEMBL7538071 | 0.73 | EDNRA (0.54) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |