Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 4/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947118 | 0.92 | SCN9A (0.44) | — | |
| SCHEMBL8623773 | 0.89 | EDNRB (0.50) | EDNRBEDNRA | |
| SCHEMBL7535022 | 0.88 | CTNNB1 (0.40) | EDNRBHSP90AA1HSP90AB1TERTEDNRA | |
| SCHEMBL8622123 | 0.86 | SCN9A (0.46) | EDNRBTERTEDNRA | |
| SCHEMBL8621791 | 0.84 | EDNRA (0.46) | EDNRBEDNRA | |
| SCHEMBL8620562 | 0.83 | FABP7 (0.52) | EDNRBEDNRA | |
| SCHEMBL7534434 | 0.83 | PTGS2 (0.43) | — | |
| SCHEMBL8678053 | 0.78 | EDNRA (0.53) | EDNRBEDNRA | |
| SCHEMBL8625505 | 0.75 | PRKCI (0.47) | — | |
| SCHEMBL7534280 | 0.73 | PTGS2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |