SCHEMBL8623932

SCHEMBL8623932

CC(C(Cc1ccc(Cl)cc1)c1ccc(Br)cc1)N1C(=O)c2ccccc2C1=O

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.45
MDM2 Q00987 2/20 0.44
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
MAPT P10636 1/20 0.40
SDCBP O00560 2/20 0.39
SDC2 P34741 2/20 0.39
CHRM5 P08912 1/20 0.39
CHRM1 P11229 1/20 0.39
CHRM3 P20309 1/20 0.39
GAA P10253 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CA12 O43570 1/20 0.37
CA9 Q16790 1/20 0.37
POLB P06746 1/20 0.37
FDFT1 P37268 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8624957 0.88 FDFT1 (0.48) TDP1MEN1KMT2AMAPTSDCBP
SCHEMBL8621323 0.81 FDFT1 (0.39) TDP1MEN1KMT2AMAPTSDCBP
SCHEMBL4071092 0.76 MEN1 (0.46) MDM2MEN1KMT2AMAPTCHRM5
SCHEMBL8622314 0.73 TDP1 (0.48) TDP1MDM2MEN1KMT2AMAPT
SCHEMBL8619498 0.73 SLC6A2 (0.53) MEN1KMT2AFDFT1
SCHEMBL8623146 0.73 KMT2A (0.46) MEN1KMT2AFDFT1
SCHEMBL8199320 0.73 KMT2A (0.46) MEN1KMT2AFDFT1
SCHEMBL12845880 0.71 KMT2A (0.55) TDP1MDM2MEN1KMT2AMAPT
SCHEMBL2002904 0.71 LMNA (0.47) TDP1MEN1KMT2AMAPTALDH1A1
SCHEMBL31706143 0.71 LMNA (0.47) TDP1MEN1KMT2AMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5777150-A Substituted amic acid derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1998-07-07 US disclosed