Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626480 | 0.81 | CA12 (0.36) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL8286622 | 0.79 | CA12 (0.62) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL2341320 | 0.79 | CA12 (0.34) | CA12CA1CA2CA9ALDH1A1 | |
| Water SCHEMBL8585338 | 0.77 | CA12 (0.35) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL2337867 | 0.76 | PLK1 (0.36) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL4264934 | 0.76 | LATS1 (0.40) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL6619220 | 0.76 | CA12 (0.34) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL8631741 | 0.76 | CA12 (0.38) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL6619437 | 0.76 | CXCR2 (0.35) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL8627414 | 0.75 | ALDH1A1 (0.39) | CA12CA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |