Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 13/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8624828 | 0.92 | GRIA2 (0.45) | GRIA2CA12CA1CA2CA9 | |
| SCHEMBL8625419 | 0.90 | GRIA2 (0.58) | GRIA2CA12CA1CA2CA9 | |
| SCHEMBL8561528 | 0.82 | GRIA2 (0.50) | GRIA2CA12CA1CA2CA9 | |
| SCHEMBL14415245 | 0.81 | GRIA2 (0.51) | GRIA2CA12CA1CA2CA9 | |
| SCHEMBL8625722 | 0.81 | GRIA2 (0.42) | GRIA2CA12CA1CA2CA9 | |
| SCHEMBL8556566 | 0.75 | GRIA2 (0.35) | GRIA2CA12CA1CA2CA9 | |
| SCHEMBL8627050 | 0.74 | GRIA2 (0.38) | GRIA2CA12CA1CA2CA9 | |
| SCHEMBL18186896 | 0.74 | PIK3CD (0.39) | GRIA2CA12CA1CA2CA9 | |
| SCHEMBL28750433 | 0.71 | GRIA2 (0.42) | GRIA2 | |
| SCHEMBL5620265 | 0.70 | GRIA2 (0.72) | GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |