Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 4/20 | 0.40 |
| ▸ | KDM4A | O75164 | 3/20 | 0.40 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | PHF2 | O75151 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622462 | 0.87 | THRA (0.65) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL8624400 | 0.85 | THRA (0.49) | THRATHRBSIRT3ABCB11CHRM2 | |
| SCHEMBL8618893 | 0.84 | THRA (0.56) | THRATHRBSMPD1KDM5AKDM4A | |
| SCHEMBL8623690 | 0.84 | THRA (0.50) | THRATHRBSIRT3ABCB11CHRM2 | |
| SCHEMBL8642130 | 0.81 | THRA (0.50) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL8621630 | 0.80 | THRA (0.53) | THRATHRBSMPD1KDM5AKDM4A | |
| SCHEMBL8621620 | 0.80 | THRA (0.67) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL8642126 | 0.79 | THRA (0.49) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL8624399 | 0.77 | THRA (0.47) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL8624416 | 0.76 | THRA (0.49) | THRATHRBSMPD1ABCB11CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |