SCHEMBL8626745

SCHEMBL8626745

[c]1nncn1-c1cccnc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 4/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2E1 P05181 2/20 0.41
PI4KA P42356 1/20 0.40
PI4K2B Q8TCG2 1/20 0.40
PI4K2A Q9BTU6 1/20 0.40
PI4KB Q9UBF8 1/20 0.40
HTT P42858 1/20 0.40
CHRNB2 P17787 5/20 0.38
CHRNA4 P43681 5/20 0.38
EP300 Q09472 1/20 0.38
KAT2B Q92831 1/20 0.38
CHRNA5 P30532 1/20 0.36
ELANE P08246 1/20 0.36
CHRNA7 P36544 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9168715 0.72 CYP2A6 (0.47) CYP2A6CYP3A4CYP2E1PI4KAPI4K2B
SCHEMBL11122638 0.70 CYP2A6 (0.64) CYP2A6CYP3A4CYP2E1HTTCHRNB2
SCHEMBL31440787 0.70 CYP2A6 (0.64) CYP2A6CYP3A4CYP2E1HTTCHRNB2
SCHEMBL4485626 0.68 CYP2A6 (0.47) CYP2A6CYP3A4CYP2E1PI4KAPI4K2B
SCHEMBL7306890 0.67 CHRNB2 (0.42) CYP2A6CYP3A4CYP2E1PI4KAPI4K2B
SCHEMBL3612710 0.64 NOTUM (0.62) CYP2A6CYP3A4HTTCHRNB2CHRNA4
SCHEMBL5832873 0.63 CYP2A6 (0.67) CYP2A6CYP3A4CYP2E1HTTCHRNB2
SCHEMBL29482044 0.63 CYP2A6 (0.53) CYP2A6CYP3A4CYP2E1HTTCHRNB2
SCHEMBL27857562 0.63 CYP2A6 (0.53) CYP2A6CYP3A4CYP2E1HTTCHRNB2
SCHEMBL23576586 0.63 PI4KA (0.46) CYP2A6CYP3A4CYP2E1PI4KAPI4K2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE35754-E FOR TREATING BACTERIAL INFECTIONS HOECHST AKTIENGESELLSCHAFT (DE) 1998-03-24 US disclosed
US-5710146-A ANTIBIOTICS FOR BACTERICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1998-01-20 US disclosed
US-5089490-A Cephem derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1992-02-18 US disclosed
US-4758556-A Cephem derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1988-07-19 US disclosed
US-4399131-A Cephem derivatives HOECHST AG (DE) 1983-08-16 US disclosed
US-4278793-A ANTIBIOTICS, BACTERICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1981-07-14 US disclosed