SCHEMBL8626809

SCHEMBL8626809

C#Cc1ccc2cccc(/C(=C\OC)C(=O)O)c2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C2 P52895 1/20 0.44
MTNR1A P48039 1/20 0.39
CYP2C9 P11712 3/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
PARP1 P09874 1/20 0.35
PLA2G2D Q9UNK4 1/20 0.34
CYP1A1 P04798 2/20 0.33
CYP1B1 Q16678 2/20 0.33
NR4A1 P22736 1/20 0.33
NR4A2 P43354 1/20 0.33
NR4A3 Q92570 1/20 0.33
FFAR1 O14842 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
AKR1C3 P42330 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4159791 1.00 AKR1C2 (0.44) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4
SCHEMBL8972907 0.86 AKR1C2 (0.48) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4
SCHEMBL8973400 0.85 AKR1C2 (0.45) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4
SCHEMBL8972368 0.83 AKR1C2 (0.43) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4
SCHEMBL8972398 0.83 AKR1C2 (0.43) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4
SCHEMBL8961310 0.83 AKR1C2 (0.43) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4
SCHEMBL8891576 0.83 AKR1C2 (0.46) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4
SCHEMBL8598938 0.83 AKR1C2 (0.46) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4
SCHEMBL8891560 0.83 AKR1C2 (0.46) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4
SCHEMBL8598935 0.83 AKR1C2 (0.46) AKR1C2MTNR1ACYP2C9CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0819111-A1 FUNGICIDAL COMPOUNDS AgrEvo UK Limited (GB) 1998-01-21 EP disclosed
WO-1996029301-A1 FUNGICIDAL COMPOUNDS AGREVO UK LIMITED (GB) 1996-09-26 WO disclosed