Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 4/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632316 | 0.91 | PTGS1 (0.40) | PTGS2PTGS1F10CA2CA9 | |
| SCHEMBL8635575 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1SMN1; SMN2CA2CA9 | |
| SCHEMBL8630040 | 0.86 | POLB (0.36) | PTGS2F10LRRK2CA2CA9 | |
| SCHEMBL8633695 | 0.86 | F10 (0.39) | PTGS2PTGS1F10LRRK2CA2 | |
| SCHEMBL8630025 | 0.85 | PTGS2 (0.58) | PTGS2PTGS1LMNAF10CA2 | |
| SCHEMBL8632173 | 0.85 | F10 (0.36) | PTGS2PTGS1F10LRRK2CA2 | |
| SCHEMBL8629841 | 0.85 | PTGS2 (0.39) | PTGS2PTGS1F10LRRK2CA2 | |
| SCHEMBL8631591 | 0.85 | PTGS2 (0.41) | PTGS2SMN1; SMN2F10CA2CA9 | |
| SCHEMBL8629349 | 0.84 | PTGS2 (0.48) | PTGS2PTGS1LMNAF10LRRK2 | |
| SCHEMBL8630470 | 0.81 | PTGS2 (0.49) | PTGS2PTGS1F10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |