Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631587 | 0.80 | CA7 (0.43) | GSK3BKDM4CCYP3A4 | |
| SCHEMBL9261326 | 0.75 | FFAR4 (0.33) | NFATC1GSK3BDYRK1ACYP3A4CYP2D6 | |
| SCHEMBL9257345 | 0.72 | FFAR4 (0.33) | NFATC1GSK3BDYRK1ACYP3A4CYP2D6 | |
| SCHEMBL8623915 | 0.72 | PTPN1 (0.36) | CYP3A4 | |
| SCHEMBL8625943 | 0.71 | GAA (0.35) | — | |
| SCHEMBL8626885 | 0.70 | KDM4C (0.33) | KDM4C | |
| SCHEMBL24669482 | 0.66 | USP2 (0.32) | NFATC1GSK3BDYRK1ACYP3A4CYP2D6 | |
| SCHEMBL8556566 | 0.66 | GRIA2 (0.35) | CYP3A4CYP2D6TSHR | |
| SCHEMBL8557791 | 0.65 | GRIA1 (0.34) | — | |
| SCHEMBL6618431 | 0.65 | NAMPT (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |