Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.46 |
| ▸ | NAMPT | P43490 | 12/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632203 | 0.92 | EGLN1 (0.46) | EGLN1 | |
| SCHEMBL8629874 | 0.91 | EGLN1 (0.52) | EGLN1NAMPTUSP5CA1CA2 | |
| SCHEMBL6564105 | 0.88 | EGLN1 (0.48) | EGLN1NAMPTCA1CA2 | |
| SCHEMBL8627667 | 0.85 | EGLN1 (0.51) | EGLN1NAMPT | |
| SCHEMBL8629451 | 0.83 | EGLN1 (0.55) | EGLN1 | |
| SCHEMBL6567419 | 0.83 | EGLN1 (0.51) | EGLN1CA1CA2 | |
| SCHEMBL6567197 | 0.83 | EGLN1 (0.55) | EGLN1 | |
| SCHEMBL8627737 | 0.83 | EGLN1 (0.45) | EGLN1 | |
| SCHEMBL8628487 | 0.82 | EGLN1 (0.50) | EGLN1NAMPTCYP2C9CA12CA1 | |
| SCHEMBL8629876 | 0.82 | EGLN1 (0.51) | EGLN1NAMPTUSP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |