Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630717 | 1.00 | KAT8 (0.49) | KAT8EGLN1PPARATLR8EGLN3 | |
| SCHEMBL8626278 | 1.00 | KAT8 (0.49) | KAT8EGLN1PPARATLR8EGLN3 | |
| SCHEMBL8629523 | 0.95 | EGLN1 (0.48) | KAT8EGLN1EGLN3FTOKDM5B | |
| SCHEMBL8632089 | 0.91 | EGLN1 (0.50) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL6566238 | 0.83 | EGLN1 (0.47) | EGLN1EGLN3FTOPDE2APDE3B | |
| SCHEMBL6567473 | 0.76 | EGLN1 (0.54) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL6566125 | 0.76 | EGLN1 (0.52) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL8632084 | 0.75 | EGLN1 (0.59) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL6565865 | 0.75 | EGLN1 (0.57) | EGLN1EGLN3FTO | |
| SCHEMBL8625366 | 0.74 | EGLN1 (0.44) | EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |