Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 17/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 5/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.44 |
| ▸ | VEGFA | P15692 | 3/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629523 | 0.93 | EGLN1 (0.48) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL8628922 | 0.91 | KAT8 (0.49) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL8630717 | 0.91 | KAT8 (0.49) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL8626278 | 0.91 | KAT8 (0.49) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL8628951 | 0.87 | EGLN1 (0.43) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL8628375 | 0.81 | EGLN1 (0.42) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL964980 | 0.80 | EGLN1 (0.50) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL1509148 | 0.80 | EGLN1 (0.50) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL968220 | 0.80 | EGLN1 (0.56) | EGLN1EGLN3FTOKDM5BKDM2A | |
| SCHEMBL6567473 | 0.80 | EGLN1 (0.54) | EGLN1EGLN3FTOKDM5BKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |