Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629215 | 1.00 | CYSLTR2 (0.44) | CYSLTR2CYSLTR1PTPRCPTPN1SMN1; SMN2 | |
| SCHEMBL8633946 | 0.83 | CYSLTR1 (0.41) | CYSLTR2CYSLTR1 | |
| SCHEMBL8633949 | 0.83 | CYSLTR1 (0.41) | CYSLTR2CYSLTR1 | |
| SCHEMBL9174756 | 0.83 | CYSLTR2 (0.44) | CYSLTR2CYSLTR1PTPRCPTPN1 | |
| SCHEMBL9174760 | 0.83 | CYSLTR2 (0.44) | CYSLTR2CYSLTR1PTPRCPTPN1 | |
| SCHEMBL9108247 | 0.83 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1PTPRCPTPN1SMN1; SMN2 | |
| SCHEMBL9108250 | 0.83 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1PTPRCPTPN1SMN1; SMN2 | |
| SCHEMBL201961 | 0.79 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1 | |
| SCHEMBL30497375 | 0.79 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1 | |
| SCHEMBL29517073 | 0.79 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0565185-B1 | Quinoline derivatives as leukotriene antagonists | MERCK FROSST CANADA INC (CA) | 1998-07-08 | — | — | EP | disclosed |
| US-5270324-A | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists | MERCK FROSST CANADA, INC. (CA) | 1993-12-14 | — | — | US | disclosed |
| WO-1993021159-A1 | QUINOLINE DERIVATIVES AS LEUKOTRIENE ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1993-10-28 | — | — | WO | disclosed |
| EP-0565185-A1 | Quinoline derivatives as leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1993-10-13 | — | — | EP | disclosed |