SCHEMBL8629558

SCHEMBL8629558

C=CCOC(=O)C(O)(Cl)CCl

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.36
TSHR P16473 2/20 0.34
MAPT P10636 1/20 0.34
CACNA1B Q00975 1/20 0.34
APBA1 Q02410 1/20 0.34
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2825649 0.84 CYP3A4 (0.36) CYP3A4TSHRMAPTCACNA1BAPBA1
SCHEMBL7094910 0.79 CYP3A4 (0.41) CYP3A4TSHRMAPTCACNA1BAPBA1
Ammonia Solution, Strong SCHEMBL10836805 0.77 CYP3A4 (0.39) CYP3A4TSHRMAPTCACNA1BAPBA1
SCHEMBL10823258 0.76 TSHR (0.38) CYP3A4TSHRMAPTCACNA1BAPBA1
SCHEMBL2364280 0.75 CYP3A4 (0.38) CYP3A4TSHRMAPTCACNA1BAPBA1
SCHEMBL8586425 0.75 CYP3A4 (0.38) CYP3A4TSHRMAPTCACNA1BAPBA1
SCHEMBL10587973 0.75 TSHR (0.40) CYP3A4TSHRMAPTCACNA1BAPBA1
SCHEMBL5461645 0.74 TSHR (0.53) TSHRMAPTMEN1KMT2A
SCHEMBL5282910 0.73 CYP3A4 (0.37) CYP3A4TSHRMAPTCACNA1BAPBA1
SCHEMBL6194635 0.72 TSHR (0.41) CYP3A4TSHRMAPTCACNA1BAPBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10273473-A None JP disclosed
JP-H10273473-A PRODUCTION OF ALKALI METAL AND/OR AMMONIUM SALT OF ALPHA-CHLORO-ACRYLIC ACID AND/OR CROTONIC ACID CLARIANT FINANCE BVI LTD 1998-10-13 JP disclosed