Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 17/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.40 |
| ▸ | VEGFA | P15692 | 3/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567446 | 0.90 | EGLN1 (0.46) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL8632215 | 0.88 | EGLN1 (0.46) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL6567188 | 0.88 | EGLN1 (0.47) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL8779216 | 0.86 | EGLN1 (0.49) | EGLN1EGLN3FTOVEGFAFLT1 | |
| Hydrochloric Acid SCHEMBL6565656 | 0.85 | EGLN1 (0.48) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL8625570 | 0.84 | MAPT (0.45) | USP2MAPTTSHRPDE2APDE3B | |
| SCHEMBL27462481 | 0.80 | KMT2A (0.42) | EGLN1USP2MAPTTSHR | |
| SCHEMBL967780 | 0.80 | EGLN1 (0.48) | EGLN1EGLN3FTO | |
| SCHEMBL6566125 | 0.78 | EGLN1 (0.52) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL6564074 | 0.78 | EGLN1 (0.45) | EGLN1EGLN3FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |