Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.46 |
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | VEGFA | P15692 | 3/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779216 | 0.89 | EGLN1 (0.49) | EGLN1EGLN3FTOVEGFAFLT1 | |
| Hydrochloric Acid SCHEMBL6565656 | 0.89 | EGLN1 (0.48) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL8630490 | 0.88 | EGLN1 (0.43) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL6567188 | 0.88 | EGLN1 (0.47) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL6567446 | 0.86 | EGLN1 (0.46) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL967780 | 0.83 | EGLN1 (0.48) | EGLN1EGLN3FTO | |
| SCHEMBL8628688 | 0.83 | HTT (0.41) | HTTKMT2ASMN1; SMN2 | |
| SCHEMBL6566125 | 0.82 | EGLN1 (0.52) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL6566160 | 0.81 | EGLN1 (0.47) | EGLN1EGLN3FTO | |
| SCHEMBL8627737 | 0.81 | EGLN1 (0.45) | EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | claimed |
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |