SCHEMBL8631077

SCHEMBL8631077

Nc1nc2c(N)cc(C(=O)O)cc2s1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.45
NSD1 Q96L73 2/20 0.44
ALDH1A1 P00352 5/20 0.42
LMNA P02545 3/20 0.42
HSD17B10 Q99714 1/20 0.42
CSNK2A1 P68400 1/20 0.42
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
KDM4E B2RXH2 3/20 0.40
POLB P06746 2/20 0.40
GAA P10253 2/20 0.40
MAPT P10636 2/20 0.40
HPGD P15428 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
NFKB1 P19838 2/20 0.40
NFKB2 Q00653 2/20 0.40
RELA Q04206 2/20 0.40
MITF O75030 1/20 0.40
RECQL P46063 1/20 0.40
GFER P55789 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24987313 0.85 CYP2C19 (0.60) CYP2C19NSD1ALDH1A1LMNAHSD17B10
SCHEMBL2911344 0.83 NSD1 (0.49) CYP2C19NSD1ALDH1A1LMNAHSD17B10
SCHEMBL26962466 0.83 HSD17B10 (0.60) CYP2C19NSD1ALDH1A1LMNAHSD17B10
SCHEMBL23196210 0.83 ALDH1A1 (0.51) CYP2C19NSD1ALDH1A1LMNAHSD17B10
SCHEMBL10432129 0.83 CYP2C19 (0.49) CYP2C19ALDH1A1LMNAHSD17B10NPC1
SCHEMBL2652019 0.81 CYP2C19 (0.44) CYP2C19NSD1ALDH1A1LMNAHSD17B10
SCHEMBL20554137 0.80 CYP3A4 (0.51) CYP2C19NSD1HSD17B10CSNK2A1MAPT
SCHEMBL23196255 0.76 CYP2C19 (0.39) CYP2C19NSD1ALDH1A1LMNAHSD17B10
SCHEMBL23195868 0.76 NPC1 (0.42) CYP2C19NSD1ALDH1A1LMNAHSD17B10
SCHEMBL21264331 0.76 TOP2A (0.41) CYP2C19NSD1ALDH1A1LMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0614915-B1 Polymer scale preventive agent SHINETSU CHEMICAL CO (JP) 1998-06-24 EP disclosed
US-5420214-A Process to prevent scale adhesion using condensation product of a diamino heterocyclic and a quinone SHIN-ETSU CHEMICAL CO., LTD. (JP) 1995-05-30 US disclosed
EP-0614915-A1 Polymer scale preventive agent Shin-Etsu Chemical Co., Ltd. (JP) 1994-09-14 EP disclosed