⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572902 | 0.78 | — | — | |
| SCHEMBL2199610 | 0.75 | — | — | |
| SCHEMBL8529308 | 0.71 | — | — | |
| SCHEMBL5361128 | 0.71 | — | — | |
| SCHEMBL6563254 | 0.69 | — | — | |
| SCHEMBL4708134 | 0.69 | — | — | |
| SCHEMBL23093208 | 0.68 | HSD17B10 (0.30) | — | |
| SCHEMBL1226347 | 0.66 | — | — | |
| SCHEMBL23093206 | 0.65 | ADRB2 (0.32) | — | |
| SCHEMBL8599018 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834214-A1 | DERIVATIVES OF 1-(2-HALO-BIPHENYL-4-YL)- ALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Chiesi Farmaceutici S.p.A. (IT) | 2015-02-11 | — | — | EP | disclosed |
| US-8835494-B2 | Derivatives of 1-(2-halo-biphenyl-4-yl)-Alkanecarboxylic for the treatment of neurodegenerative diseases | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-09-16 | — | — | US | disclosed |
| WO-2013150072-A1 | DERIVATIVES OF 1-(2-HALO-BIPHENYL-4-YL)- ALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-10-10 | — | — | WO | disclosed |
| US-20130267592-A1 | DERIVATIVES OF 1-(2-HALO-BIPHENYL-4-YL)-ALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-10-10 | — | — | US | disclosed |
| EP-0847399-A1 | NOVEL ESTROGENS | Astra Aktiebolag (SE) | 1998-06-17 | — | — | EP | disclosed |
| WO-1997008188-A1 | NOVEL ESTROGENS | ASTRA AKTIEBOLAG (SE) | 1997-03-06 | — | — | WO | disclosed |
| WO-1992004339-A1 | NOVEL PROSTAGLANDIN I2 DERIVATIVES | ASAHI GLASS COMPANY LTD. (JP) | 1992-03-19 | — | — | WO | disclosed |
| US-4699989-A | 7-fluoroprostaglandins and process for their production | ASAHI GLASS COMPANY LTD. (JP) | 1987-10-13 | — | — | US | disclosed |