Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.43 |
| ▸ | F10 | P00742 | 6/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632163 | 0.93 | PTGS2 (0.43) | PTGS2PTGS1F10PI4KBPDE4A | |
| SCHEMBL8631466 | 0.92 | PTGS2 (0.42) | PTGS2PTGS1F10PI4KBPDE4A | |
| SCHEMBL8629873 | 0.90 | PTGS2 (0.41) | PTGS2PTGS1F10PI4KBPDE4A | |
| SCHEMBL7779745 | 0.88 | PTGS2 (0.49) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL8634273 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1F10ALDH1A1F2 | |
| SCHEMBL8634846 | 0.86 | PTGS2 (0.41) | PTGS2PTGS1F10PI4KBERN1 | |
| SCHEMBL8630545 | 0.84 | AR (0.38) | PTGS2PTGS1F10SMN1; SMN2F2 | |
| SCHEMBL8630470 | 0.84 | PTGS2 (0.49) | PTGS2PTGS1F10ALDH1A1ABCB11 | |
| SCHEMBL7779264 | 0.84 | PTGS2 (0.46) | PTGS2PTGS1PI4KB | |
| SCHEMBL8635053 | 0.83 | PTGS1 (0.44) | PTGS2PTGS1F10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |