SCHEMBL8634816

SCHEMBL8634816

CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccc(Cl)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 14/20 1.00
CCKAR P32238 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8638925 0.96 CCKBR (1.00) CCKBR
SCHEMBL8639233 0.91 CCKBR (1.00) CCKBR
SCHEMBL8635376 0.89 CCKBR (1.00) CCKBRCCKAR
SCHEMBL8634884 0.89 CCKBR (0.93) CCKBRCCKAR
SCHEMBL8615569 0.84 CCKBR (0.73) CCKBR
SCHEMBL8617280 0.80 CCKBR (0.67) CCKBRCCKAR
SCHEMBL8618358 0.80 CCKBR (0.66) CCKBR
SCHEMBL8618681 0.79 CCKBR (0.65) CCKBR
SCHEMBL8638093 0.79 CCKBR (1.00) CCKBR
SCHEMBL8615675 0.78 CCKBR (0.74) CCKBRCCKAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0558104-B1 1,5-Benzodiazepine derivatives and their use in medicine GLAXO WELLCOME SPA (IT) 1998-07-29 EP disclosed
US-5637697-A ANTAGONIST TO GASTRIN AND(OR) CHLOROCYSTOKININ GLAXO SPA (IT) 1997-06-10 US disclosed
US-5580895-A GASTROINTESTINAL OR CENTRAL NERVOUS SYSTEM DISORDERS GLAXO SPA (IT) 1996-12-03 US disclosed
EP-0558104-A1 1,5-Benzodiazepine derivatives and their use in medicine GLAXO S.p.A. (IT) 1993-09-01 EP disclosed