SCHEMBL8635008

SCHEMBL8635008

CCCC(=O)ON1CCN(c2ccncc2)CC1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 4/20 0.44
ITGA2B P08514 4/20 0.44
HRH3 Q9Y5N1 4/20 0.44
CYP2C9 P11712 2/20 0.43
TSHR P16473 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP3A4 P08684 1/20 0.43
HIF1A Q16665 1/20 0.43
ALDH1A1 P00352 1/20 0.43
GAA P10253 1/20 0.43
CHKA P35790 1/20 0.42
CHRM1 P11229 1/20 0.42
SPHK1 Q9NYA1 1/20 0.40
HTT P42858 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8837976 0.99 ITGB3 (0.43) ITGB3ITGA2BHRH3CYP2C9TSHR
SCHEMBL8637100 0.91 HRH3 (0.44) ITGB3ITGA2BHRH3CYP2C9TSHR
Hydrochloric Acid SCHEMBL8837971 0.91 HRH3 (0.44) ITGB3ITGA2BHRH3CYP2C9TSHR
SCHEMBL8837993 0.88 HRH3 (0.48) ITGB3ITGA2BHRH3CYP2C9TSHR
Hydrochloric Acid SCHEMBL8838107 0.87 HRH3 (0.47) ITGB3ITGA2BHRH3CYP2C9TSHR
SCHEMBL8837938 0.85 CHKA (0.47) ITGB3ITGA2BHRH3CYP2C9TSHR
Hydrochloric Acid SCHEMBL8838098 0.84 CHKA (0.46) ITGB3ITGA2BHRH3CYP2C9TSHR
SCHEMBL8838198 0.82 GAA (0.44) ITGB3ITGA2BHRH3CYP2C9TSHR
SCHEMBL8837943 0.81 ITGB3 (0.48) ITGB3ITGA2BHRH3HIF1ACHKA
SCHEMBL8838126 0.80 CYP2C9 (0.51) ITGB3ITGA2BHRH3CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753659-A ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, ZENECA LIMITED (GB) 1998-05-19 US disclosed
US-5750754-A TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS ZENECA LIMITED (GB) 1998-05-12 US disclosed
US-5700801-A ANTIINFLAMMATORY AGENTS, BONE DISORDERS KARL THOMAE, GMBH (DE) 1997-12-23 US disclosed