Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502449 | 0.81 | ESR2 (0.38) | MAP1LC3BGAAKDM4EALDH1A1 | |
| SCHEMBL6953228 | 0.70 | HCAR2 (0.43) | HCAR2MAP1LC3BGAAKDM4EGRM2 | |
| SCHEMBL7503939 | 0.70 | — | — | |
| SCHEMBL434672 | 0.70 | KDM4E (0.50) | HCAR2GAAKDM4EGRM2PROKR1 | |
| SCHEMBL316350 | 0.70 | KDM4E (0.55) | GAAKDM4EGRM2PROKR1DRD2 | |
| SCHEMBL128052 | 0.68 | KDM4E (0.53) | GAAKDM4EGRM2DRD2DRD3 | |
| Ammonia Solution, Strong SCHEMBL17982788 | 0.68 | KDM4E (0.48) | HCAR2GAAKDM4EGRM2PROKR1 | |
| SCHEMBL6696358 | 0.68 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL29436912 | 0.68 | KDM4E (0.53) | GAAKDM4EGRM2DRD2DRD3 | |
| SCHEMBL17068945 | 0.68 | KDM4E (0.53) | GAAKDM4EGRM2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601191-B1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 1998-07-22 | — | — | EP | disclosed |
| EP-0601191-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1994-06-15 | — | — | EP | disclosed |