Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SIK1 | P57059 | 1/20 | 0.34 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.34 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421706 | 0.93 | FGFR1 (0.37) | FGFR1SRCDYRK1ATSHRMEN1 | |
| SCHEMBL8419025 | 0.92 | FGFR1 (0.36) | FGFR1SRCDYRK1AMEN1KMT2A | |
| SCHEMBL8419090 | 0.89 | FGFR1 (0.36) | FGFR1SRCDYRK1AALDH1A1HTT | |
| SCHEMBL8419222 | 0.88 | FGFR1 (0.36) | FGFR1SRCDYRK1AALDH1A1HTT | |
| SCHEMBL8422153 | 0.87 | FGFR1 (0.35) | FGFR1SRCDYRK1AMEN1KMT2A | |
| SCHEMBL8417944 | 0.87 | FGFR1 (0.35) | FGFR1SRCDYRK1AALDH1A1HTT | |
| SCHEMBL8418025 | 0.86 | FGFR1 (0.34) | FGFR1SRCDYRK1AHTTTSHR | |
| SCHEMBL8519657 | 0.86 | FGFR1 (0.34) | FGFR1SRCDYRK1AALDH1A1HTT | |
| SCHEMBL8417985 | 0.85 | FGFR1 (0.34) | FGFR1SRCDYRK1AALDH1A1MEN1 | |
| SCHEMBL8421182 | 0.85 | PRKDC (0.38) | FGFR1ALDH1A1TSHRMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763619-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS OR STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5703110-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-30 | — | — | US | disclosed |