Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421430 | 0.95 | RIPK1 (0.37) | FGFR1SRCESR1ESR2DYRK1A | |
| SCHEMBL8417944 | 0.94 | FGFR1 (0.35) | FGFR1SRCESR1ESR2DYRK1A | |
| SCHEMBL8419090 | 0.90 | FGFR1 (0.36) | FGFR1SRCESR1ESR2DYRK1A | |
| SCHEMBL8421146 | 0.88 | GABRG2 (0.34) | MEN1KMT2AALDH1A1 | |
| SCHEMBL8419025 | 0.87 | FGFR1 (0.36) | FGFR1SRCDYRK1AMEN1KMT2A | |
| SCHEMBL8421706 | 0.87 | FGFR1 (0.37) | FGFR1SRCESR1ESR2DYRK1A | |
| SCHEMBL8419430 | 0.86 | TSHR (0.37) | MEN1KMT2A | |
| SCHEMBL8635495 | 0.85 | FGFR1 (0.42) | FGFR1SRCESR1ESR2DYRK1A | |
| SCHEMBL8421731 | 0.85 | FGFR1 (0.33) | FGFR1SRCDYRK1AMEN1KMT2A | |
| SCHEMBL8519657 | 0.85 | FGFR1 (0.34) | FGFR1SRCESR1ESR2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962491-A | ANGIOTENSIN ANTAGONIST, HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |