Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 8/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636076 | 0.84 | FKBP1A (0.49) | FKBP1APREPALDH1A1CYP3A4TSHR | |
| SCHEMBL4602602 | 0.81 | SPHK2 (0.58) | SPHK2PREPTSHR | |
| SCHEMBL5267939 | 0.81 | SPHK2 (0.58) | SPHK2PREPTSHR | |
| SCHEMBL809494 | 0.81 | SPHK2 (0.58) | SPHK2PREPTSHR | |
| SCHEMBL16347238 | 0.81 | TSHR (0.55) | FKBP1AALDH1A1TSHR | |
| SCHEMBL17766262 | 0.81 | TSHR (0.55) | FKBP1AALDH1A1TSHR | |
| SCHEMBL8639478 | 0.81 | PREP (0.65) | FKBP1APREPTSHR | |
| SCHEMBL23963491 | 0.80 | SPHK2 (0.57) | SPHK2FKBP1APOLBPREP | |
| SCHEMBL1190565 | 0.80 | SPHK2 (0.54) | SPHK2FKBP1APREP | |
| SCHEMBL3605585 | 0.80 | SPHK2 (0.54) | SPHK2FKBP1APREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |